10 To our pleasure, the reaction goes much faster under these conditions, and a high yield of 92% of the product was obtained in about 2 h (entry 3). This discovery encouraged us to further explore green reaction conditions without the usage of the organic solvent for this reaction. When 2.5 mol % of the Cd-MOF was added, 66% of the desired product 4a was obtained under similar conditions (entry 2). Without catalyst, no product was obtained after 6 h of reflux in EtOH (entry 1).
HCarried out with 0.5 mol % of the catalyst.
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These Cd(4,4′-bpe) 2(H 2O) 4 moieties are bridged by the free m-BDS molecules by hydrogen bonding to form two-dimensional hydrogen bonded framework ( Figure 1). As shown in Figure S1, 9 the Cd ion is coordinated by two 4,4′-bpe and four water molecules in octahedral coordination geometry. 8 Their crystal structures were characterized by single x-ray diffraction and purity of the phases were confirmed by powder XRD. The Zn- and Cd-MOFs were readily synthesized from hydrothermal reactions from their corresponding metal salts and organic linkers 4,4′-bpe and m-BDS as single crystals in high yield.
The Biginelli reaction, 3 the three-component reaction between aldehydes, urea, and acetoacetate, is one of the most efficient ways to synthesize dihydropyrimidinone derivatives, which are important pharmacological compounds. Although a variety of heterogenization approaches such as anchoring catalysts onto porous inorganic materials, organic polymers, dendrimers supports and metal-organic frameworks (MOFs) have been explored most heterogenized catalysts suffer from the reduced catalytic activity and efficiency. Heterogenization of homogeneous catalysts has been of great academic and industrial importance, because the heterogenized catalysts have the advantages to be recoverable, reusable and environmentally friendly.
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